By leveraging upon technologies developed in-house or otherwise, particularly revolving around high-dimensional tissue imaging.
We seek to understand host immune responses against viruses (such as HIV, SIV, SARS-CoV-2, EBOV), cancers (eg lymphomas) and immune dysregulation (eg HIV, lymphomas, Chronic Rhinosinusitis). To maximize our success, we partner with clinical collaborators in our quest towards a systems-level understanding of the immune-disease interface through 1) archival clinical samples, 2) small and large animal models and 3) organoid systems. By combining technology development with the questions above, we will decipher higher-order host-disease interactions to understand disease mechanisms with the long-term goal of improving therapeutics.
(Projects include HIV, SARS-CoV-2, EBV and EBOV)
Viruses are the best molecular biologists. Its is pertinent to appreciate virus-host interactions in their native context for a glimpse of the molecular mechanisms of how viruses usurp host defense.
(Projects include Leukemia and Lymphomas)
“Cancer cells grow faster, adapt better. They are more perfect versions of ourselves.” – Siddhartha Mukherjee, The Emperor of All Maladies. A systems-level understanding of cancers in their native context will enable better ways to predict and combat them.
(Projects include HIV, Lymphomas, Chronic Rhinosinusitis and Neural-Immune Dysfunctions)
How do our defenders become the enemy? Understanding how our body’s defense can go awry is the key to building better tools to keep them in check.
50+ plex (mainly) protein fluorescence imaging in 1 single tissue section!
40+ plex (mainly) protein mass-spec imaging in 1 single tissue section!
Pathology-guided, targeted spatial transcriptomics!
Single-cell spatial transcriptomics!