Technology development
We develop chemistry and imaging that measure proteins, RNA, DNA and glycans in the same tissue section.
We develop and apply technologies to understand how the immune system responds to disease
We build what we need to ask the next question. That means new approaches to measure more molecules in the same cell, new ways to image them, and new computational and machine learning approaches to learn from what we measure.
Our work starts in tissue and is centered around patients, from cancers to viral infection and to immune diseases.
Research
Our research 
AI for biology and medicine
We build models that learn from single cells, their neighborhoods and whole tissue images.
Human-centered discovery and translation
We study viral infection, cancer and immune disease in human tissue. With our clinical partners, we work to turn what we find into better care for patients.
Recent publications
All 80 publications-
Spatial Proteomics Uncovers Immune Cell Neighborhoods and Tumor-Immune Interfaces in Pancreatic Ductal Adenocarcinoma
PDF: Spatial Proteomics Uncovers Immune Cell Neighborhoods and Tumor-Immune Interfaces in Pancreatic Ductal Adenocarcinoma 13 MBPublisher: Spatial Proteomics Uncovers Immune Cell Neighborhoods and Tumor-Immune Interfaces in Pancreatic Ductal Adenocarcinoma
-
A Human Genome-wide CRISPR-Cas9 Screen Reveals Host Factors That Support Epstein-Barr Virus B cell infection
PDF: A Human Genome-wide CRISPR-Cas9 Screen Reveals Host Factors That Support Epstein-Barr Virus B cell infection 4 MBbioRxiv: A Human Genome-wide CRISPR-Cas9 Screen Reveals Host Factors That Support Epstein-Barr Virus B cell infection
-
PASTA: versatile tyramide-oligonucleotide amplification for multimodal spatial biology
Publisher: PASTA: versatile tyramide-oligonucleotide amplification for multimodal spatial biologyFree full text: PASTA: versatile tyramide-oligonucleotide amplification for multimodal spatial biology
-
Follicular Lymphoma Transformation is Characterized by Cytokine-associated Remodeling of Stromal and Macrophage Compartments
Publisher: Follicular Lymphoma Transformation is Characterized by Cytokine-associated Remodeling of Stromal and Macrophage CompartmentsFree full text: Follicular Lymphoma Transformation is Characterized by Cytokine-associated Remodeling of Stromal and Macrophage Compartments
-
Same-Slide Spatial Multi-Omics Integration with IN-DEPTH Reveals Tumor Virus-Linked Spatial Reorganization of the Tumor Microenvironment
PDF: Same-Slide Spatial Multi-Omics Integration with IN-DEPTH Reveals Tumor Virus-Linked Spatial Reorganization of the Tumor Microenvironment 27 MBPublisher: Same-Slide Spatial Multi-Omics Integration with IN-DEPTH Reveals Tumor Virus-Linked Spatial Reorganization of the Tumor Microenvironment
People
Meet the labMeet our multi-disciplinary group of scientists.
-
Sizun Jiang
Principal Investigator
-
Lindsay Parmelee
Lab Manager
-
Chi Ngai Chan
Staff Scientist
-
Hendrik Michel
Graduate Student
-
Stephanie Yiu
Postdoctoral Fellow
Co-mentors: Don Ingber and Girija Goyal, Wyss Institute
-
Yuzhou Chang
Postdoctoral Fellow
-
Yuchen Wang
Postdoctoral Fellow
-
Khyati Meghani
Postdoctoral Fellow
Co-mentor: Brooke Howitt, Stanford
-
Rongting Huang
Postdoctoral Fellow
Co-mentor: Brooke Howitt, Stanford
-
Trinh Phan-Canh
Postdoctoral Fellow
-
Samantha Sack
Visiting Medical Student
-
Thu Pham
Postdoctoral Fellow
-
Helen Huang
Postdoctoral Fellow
Co-mentor: Venu Pillarisetty, University of Washington and Fred Hutch
-
Yuemeng Li
Research Assistant
-
Xijun Xu
Undergraduate Research Intern
Join us
We are always looking for talented future colleagues on both the computational and experimental sides.